Predominance of M2-polarized macrophages in bladder cancer affects angiogenesis, tumor grade and invasiveness.

@article{Takeuchi2016PredominanceOM,
  title={Predominance of M2-polarized macrophages in bladder cancer affects angiogenesis, tumor grade and invasiveness.},
  author={Hisashi Takeuchi and Michio Tanaka and Ayako Tanaka and Akisa Tsunemi and Hidenobu Yamamoto},
  journal={Oncology letters},
  year={2016},
  volume={11 5},
  pages={3403-3408}
}
Tumor-associated macrophages (TAMs) often assume an immunoregulatory M2 phenotype. Thus, the aim of the present study was to clarify the correlation of vascularity and TAMs, in particular the M2 phenotype in the stroma and tumor areas, with the clinical and pathological outcomes of patients with bladder cancer. The TAM counts and microvessel counts (MVCs) were determined immunohistochemically in 21 patients with bladder cancer. The number of infiltrating TAMs was measured using… CONTINUE READING

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