Prednisolone or pentoxifylline for alcoholic hepatitis.

  title={Prednisolone or pentoxifylline for alcoholic hepatitis.},
  author={M. Thursz and P. Richardson and M. Allison and A. Austin and M. Bowers and C. Day and Nichola Downs and D. Gleeson and A. Macgilchrist and A. Grant and S. Hood and S. Masson and A. McCune and J. Mellor and J. O'Grady and D. Patch and I. Ratcliffe and P. Roderick and L. Stanton and Nikhil Vergis and M. Wright and S. Ryder and E. Forrest},
  journal={The New England journal of medicine},
  volume={372 17},
  • M. Thursz, P. Richardson, +20 authors E. Forrest
  • Published 2015
  • Medicine
  • The New England journal of medicine
  • BACKGROUND Alcoholic hepatitis is a clinical syndrome characterized by jaundice and liver impairment that occurs in patients with a history of heavy and prolonged alcohol use. The short-term mortality among patients with severe disease exceeds 30%. Prednisolone and pentoxifylline are both recommended for the treatment of severe alcoholic hepatitis, but uncertainty about their benefit persists. METHODS We conducted a multicenter, double-blind, randomized trial with a 2-by-2 factorial design to… CONTINUE READING
    139 Citations

    Paper Mentions

    Interventional Clinical Trial
    The proposed study is An Open-Label, Dose Escalation Study to Assess the Safety, and Pharmacodynamics (PD) signals of DUR 928 in Patients with AH. DUR-928 will be administered in… Expand
    ConditionsAlcoholic Hepatitis
    Interventional Clinical Trial
    Approximately 50% of patients admitted for severe AH will have spontaneous improvement of liver function before initiation of therapy (ie decrease in mDF between hospital admission… Expand
    ConditionsAlcoholic Hepatitis
    Interventional Clinical Trial
    In Mexico, alcoholic liver disease is the fourth cause of mortality (INEGI). Patients with severe alcoholic hepatitis have a high mortality at 28 days and 6 months, patients receiving… Expand
    ConditionsAlcoholic Hepatitis
    InterventionDietary Supplement, Other
    Pentoxifylline is ineffective in treating severe alcoholic hepatitis
    • P. Hendy
    • Medicine
    • Frontline Gastroenterology
    • 2015
    • 2
    Therapeutic Strategies for the Treatment of Alcoholic Hepatitis.
    • 19
    Infections in severe alcoholic hepatitis
    • 2
    • Highly Influenced
    • PDF
    Acute Alcoholic Hepatitis
    Case of severe alcoholic hepatitis treated with granulocytapheresis
    • 1
    Glucocorticosteroids for people with alcoholic hepatitis.
    • 20
    • PDF


    A randomized trial of prednisolone in patients with severe alcoholic hepatitis.
    • 323
    Pentoxifylline versus prednisolone for severe alcoholic hepatitis: a randomized controlled trial.
    • 136
    • PDF
    Glucocorticoids plus N-acetylcysteine in severe alcoholic hepatitis.
    • 263
    • PDF
    Pentoxifylline for alcoholic hepatitis.
    • 97