Prednisolone or pentoxifylline for alcoholic hepatitis.

@article{Thursz2015PrednisoloneOP,
  title={Prednisolone or pentoxifylline for alcoholic hepatitis.},
  author={M. Thursz and P. Richardson and Michael Allison and A. Austin and M. Bowers and C. Day and N. Downs and D. Gleeson and A. Macgilchrist and A. Grant and S. Hood and S. Masson and A. McCune and J. Mellor and J. O'grady and D. Patch and I. Ratcliffe and P. Roderick and L. Stanton and Nikhil Vergis and M. Wright and S. Ryder and E. Forrest},
  journal={The New England journal of medicine},
  year={2015},
  volume={372 17},
  pages={
          1619-28
        }
}
BACKGROUND Alcoholic hepatitis is a clinical syndrome characterized by jaundice and liver impairment that occurs in patients with a history of heavy and prolonged alcohol use. The short-term mortality among patients with severe disease exceeds 30%. Prednisolone and pentoxifylline are both recommended for the treatment of severe alcoholic hepatitis, but uncertainty about their benefit persists. METHODS We conducted a multicenter, double-blind, randomized trial with a 2-by-2 factorial design to… Expand
140 Citations

Paper Mentions

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The proposed study is An Open-Label, Dose Escalation Study to Assess the Safety, and Pharmacodynamics (PD) signals of DUR 928 in Patients with AH. DUR-928 will be administered in… Expand
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