Prednisolone inhibits phagocytosis by polymorphonuclear leucocytes via steroid receptor mediated events.

Abstract

Prednisolone, at concentrations between 2.78 x 10(-6) M (1 mug/ml) and 1.39 x 10(-8) M (5 x 10(-3) mug/ml) exerts an inhibitory effect on the phagocytosis of latex particles by normal human polymorphonuclear leucocytes in vitro as assessed by electron microscopical analysis. This inhibition appears to be receptor-mediated, as it is dependent upon RNA and… (More)

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