Prednisolone induces osteoporosis-like phenotype in regenerating zebrafish scales

@article{Vrieze2013PrednisoloneIO,
  title={Prednisolone induces osteoporosis-like phenotype in regenerating zebrafish scales},
  author={E. D. Vrieze and M. V. Kessel and H. M. Peters and F. Spanings and G. Flik and J. Metz},
  journal={Osteoporosis International},
  year={2013},
  volume={25},
  pages={567-578}
}
SummaryWe demonstrate that glucocorticoids induce an osteoporotic phenotype in regenerating scales of zebrafish. Exposure to prednisolone results in altered mineral content, enhanced matrix breakdown, and an osteoporotic gene-expression profile in osteoblasts and osteoclasts. This highlights that the zebrafish scale provides a powerful tool for preclinical osteoporosis research.IntroductionThis study aims to evaluate whether glucocorticoid (prednisolone) treatment of zebrafish induces an… Expand
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