Prednisolone induces osteoporosis-like phenotype in regenerating zebrafish scales

@article{Vrieze2013PrednisoloneIO,
  title={Prednisolone induces osteoporosis-like phenotype in regenerating zebrafish scales},
  author={Erik de Vrieze and M. A. H. J. van Kessel and H. M. Peters and F. A. Tom Spanings and Gert Flik and Juriaan R. Metz},
  journal={Osteoporosis International},
  year={2013},
  volume={25},
  pages={567-578}
}
SummaryWe demonstrate that glucocorticoids induce an osteoporotic phenotype in regenerating scales of zebrafish. Exposure to prednisolone results in altered mineral content, enhanced matrix breakdown, and an osteoporotic gene-expression profile in osteoblasts and osteoclasts. This highlights that the zebrafish scale provides a powerful tool for preclinical osteoporosis research.IntroductionThis study aims to evaluate whether glucocorticoid (prednisolone) treatment of zebrafish induces an… 
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Immune Suppressive and Bone Inhibitory Effects of Prednisolone in Growing and Regenerating Zebrafish Tissues
  • K. Geurtzen, A. Vernet, F. Knopf
  • Biology, Medicine
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2017
TLDR
It is shown that treatment with the glucocorticoid prednisolone impacts on the number, activity and differentiation of osteoblasts, osteoclasts, and immune cells during ontogenetic growth, homeostasis, and regeneration of zebrafish bone.
Age-dependent modulation of bone metabolism in zebrafish scales as new model of male osteoporosis in lower vertebrates
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The early bone aging mechanisms in male zebrafish scales are investigated evaluating the physiological changes and the effects of prednisolone, a pro-osteoporotic drug to identify the early mechanisms of bone aging and new therapeutic strategies to prevent age-related bone alterations in humans.
Prednisolone induces osteoporosis-like phenotypes via focal adhesion signaling pathway in zebrafish larvae
TLDR
RNA deep-sequencing results show that prednisolone affects genes known to act in the extracellular region, and glucocorticoid-induced osteoporosis, and focal adhesion signaling pathway genes (itga10 and itgbl1) might be involved in GIOP.
Hydroxysafflor Yellow A Promoted Bone Mineralization and Inhibited Bone Resorption Which Reversed Glucocorticoids-Induced Osteoporosis
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HYA had the potential to prevent and heal GCIOP by promoting bone mineralization, osteoblasts viability, and bone collagen expression and inhibiting bone resorption.
Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease
TLDR
Scales have a strong osteogenic expression profile comparable to other elements of the dermal skeleton, enriched in genes that favour collagen matrix growth, and are shown to express an evolutionarily conserved sub-population of genes that are relevant to human skeletal disease.
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