Prednisolone exerts late mitogenic and biphasic effects on resistant acute lymphoblastic leukemia cells: Relation to early gene expression.

@article{Lambrou2009PrednisoloneEL,
  title={Prednisolone exerts late mitogenic and biphasic effects on resistant acute lymphoblastic leukemia cells: Relation to early gene expression.},
  author={George I. Lambrou and Spiros Vlahopoulos and Chrisanthi Papathanasiou and Maria Papanikolaou and Michael Karpusas and Emmanouil Zoumakis and Fotini Tzortzatou-Stathopoulou},
  journal={Leukemia research},
  year={2009},
  volume={33 12},
  pages={1684-95}
}
Resistance or sensitivity to glucocorticoids is considered to be of crucial importance for disease prognosis in childhood acute lymphoblastic leukemia. Prednisolone exerted a delayed biphasic effect on the resistant CCRF-CEM leukemic cell line, necrotic at low doses and apoptotic at higher doses. At low doses, prednisolone exerted a pre-dominant mitogenic effect despite its induction on total cell death, while at higher doses, prednisolone's mitogenic and cell death effects were counterbalanced… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 55 references

GRIM-19 in Health and Disease.

Advances in anatomic pathology • 2008

Methylprednisolone protects oligodendrocytes but not neurons after spinal cord injury.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2008

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