Prednisolone causes anxiety- and depression-like behaviors and altered expression of apoptotic genes in mice hippocampus.

@article{Kajiyama2010PrednisoloneCA,
  title={Prednisolone causes anxiety- and depression-like behaviors and altered expression of apoptotic genes in mice hippocampus.},
  author={Yu Kajiyama and Yoshimi Iijima and Shuichi Chiba and Miyako Furuta and Midori Ninomiya and Aiko Izumi and Shigenobu Shibata and Hiroshi Kunugi},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2010},
  volume={34 1},
  pages={159-65}
}
Glucocorticoids are known to cause psychiatric disorders including depression. Prednisolone (PSL) is one of the most widely used synthetic glucocorticoids to treat various medical diseases; however, little is known about PSL-induced behavioral changes and its molecular basis in the brain. Growing evidence has implicated that hippocampal remodeling or damage… CONTINUE READING