Prednicarbate Biotransformation in Human Foreskin Keratinocytes and Fibroblasts

@article{Gysler1997PrednicarbateBI,
  title={Prednicarbate Biotransformation in Human Foreskin Keratinocytes and Fibroblasts},
  author={Anja Gysler and Katharina Lange and Hans Christian Korting and Monika Sch{\"a}fer-Korting},
  journal={Pharmaceutical Research},
  year={1997},
  volume={14},
  pages={793-797}
}
Purpose. Evaluation of skin layer-specific prednicarbate (PC) biotransformation, possibly explaining the improved benefit/risk ratio of this topical corticosteroid in atopic dermatitis (1,2). Methods. Metabolism of PC in keratinocyte and fibroblast monolayers derived from human juvenile foreskin was evaluated. Drug concentration was determined by HPLC/UV… CONTINUE READING