Prednicarbate Biotransformation in Human Foreskin Keratinocytes and Fibroblasts

  title={Prednicarbate Biotransformation in Human Foreskin Keratinocytes and Fibroblasts},
  author={Anja Gysler and Katharina Lange and Hans Christian Korting and Monika Sch{\"a}fer-Korting},
  journal={Pharmaceutical Research},
AbstractPurpose. Evaluation of skin layer-specific prednicarbate (PC) biotransformation, possibly explaining the improved benefit/risk ratio of this topical corticosteroid in atopic dermatitis (1,2). Methods. Metabolism of PC in keratinocyte and fibroblast monolayers derived from human juvenile foreskin was evaluated. Drug concentration was determined by HPLC/UV-absorption. Accompanying cell viability tests (MTT-tests) were performed to exclude toxic drug effects. Results. Keratinocytes… 
Esterase activity in excised and reconstructed human skin--biotransformation of prednicarbate and the model dye fluorescein diacetate.
  • F. M. Bätz, W. Klipper, M. Schäfer-Korting
  • Biology, Medicine
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2013
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