Predisposition to self-administer amphetamine: the contribution of response to novelty and prior exposure to the drug

@article{Pierre1997PredispositionTS,
  title={Predisposition to self-administer amphetamine: the contribution of response to novelty and prior exposure to the drug},
  author={Peter J. Pierre and Paul Vezina},
  journal={Psychopharmacology},
  year={1997},
  volume={129},
  pages={277-284}
}
The present experiment examined the contribution of locomotor response to novelty and prior exposure to amphetamine to rats’ predisposition to self-administer a low dose of the drug. Rats were screened for their locomotor response to a novel environment and divided into high (HR) or low (LR) responders based on whether their locomotor scores were above or below the median activity level of the subject sample. Animals were then pre-exposed to nine daily injections of either saline (1 ml/kg, IP… CONTINUE READING
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