Predisposition to apoptosis in keratin 8-null liver is related to inactivation of NF-kB and SAPKs but not decreased c-Flip


Keratin 8 and 18 (K8/K18) are major intermediate filament proteins of liver hepatocytes. They provide mechanical and nonmechanical stability, thereby protecting cells from stress. Hence, K8-null mice are highly sensitive to Fas-mediated liver cell apoptosis. However, the role of c-Flip protein in K8null related susceptibility to liver injury is… (More)


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