Predisposition for disrepair in the aged lung.

  title={Predisposition for disrepair in the aged lung.},
  author={Viranuj Sueblinvong and David C. Neujahr and Stephen T. Mills and Susanne Roser-Page and Jeffrey D Ritzenthaler and David M. Guidot and M. Diaz de Rojas and Jesse Roman},
  journal={The American journal of the medical sciences},
  volume={344 1},
INTRODUCTION Idiopathic pulmonary fibrosis (IPF) is a devastating progressive lung disease with an average survival of only 3 to 5 years. The mechanisms underlying the initiation and progression of IPF are poorly understood, and treatments available have only modest effect on disease progression. Interestingly, the incidence of IPF is approximately 60 times more common in individuals aged 75 years and older, but the mechanism by which aging promotes fibrosis is unclear. The authors hypothesized… CONTINUE READING


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