Predisposing factors in occupational lung cancer: inorganic minerals and chromium.

@article{Ding2000PredisposingFI,
  title={Predisposing factors in occupational lung cancer: inorganic minerals and chromium.},
  author={Min Ding and Xianglin Shi and Vincent Castranova and Val Vallyathan},
  journal={Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer},
  year={2000},
  volume={19 1-2},
  pages={129-38}
}
Reactive oxygen species (ROS) have been implicated in the pathogenesis of cancer. Inhalation of inorganic minerals such as asbestos and crystalline silica, and metals such as arsenic, beryllium, chromium, nickel, and vanadium, may promote directly and indirectly enhanced generation of ROS at a persistent level in concert with chronic inflammation. Perpetual ROS generation can cause specific molecular changes resulting in the activation or inactivation of transcription factors that may alter… CONTINUE READING