Predisease: when does it make sense?

@article{Viera2011PrediseaseWD,
  title={Predisease: when does it make sense?},
  author={Anthony J. Viera},
  journal={Epidemiologic reviews},
  year={2011},
  volume={33},
  pages={
          122-34
        }
}
  • A. Viera
  • Published 30 May 2011
  • Medicine
  • Epidemiologic reviews
Screening often leads to finding conditions that are not at the stage or level that would classify them as disease but, at the same time, are not at a stage or level at which people can be declared entirely disease free. These "in-between" states have sometimes been designated as "predisease." Examples include precancerous lesions, increased intraocular pressure ("preglaucoma"), prediabetes, and prehypertension. When the goal of preventing adverse health outcomes is kept in mind, this review… 

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References

SHOWING 1-10 OF 119 REFERENCES
Against Diagnosis
TLDR
It is argued that, with the exception of HIV, all of these diseases are continuous, reflecting a range of severity, and that categorizing patients as either having or not having the disease depends on choosing a somewhat arbitrary cut-point of severity.
When can a risk factor be used as a worthwhile screening test?
TLDR
The quantitative relation between risk factors and screening tests is specified and it is shown how strongly a risk factor needs to be associated with a disease before it is likely to be a useful screening test.
II. “Precancerous Conditions” of the Breast
A Brief Paper on “precancerous conditions” of the breast, introductory to a discussion of the surgical and radiotherapeutic aspects of mammary cancer, can touch only on a few points of a subject
Assessing risk factors as potential screening tests: a simple assessment tool.
TLDR
An interactive Risk-Screening Converter is described, accessible from the Internet, that transforms an odds ratio into the equivalent estimates of detection and false-positive rates, and should help to distinguish effective screening methods from ineffective ones.
Premalignant lesions of the colon.
Increased absenteeism from work after detection and labeling of hypertensive patients.
TLDR
It is found that absenteeism rose 80 per cent after screening and referral among patients unaware of their hypertension before screening, which greatly exceeded the 9 per cent rise in absenteeism in the general employee population during this period.
Prevention or delay of type 2 diabetes.
TLDR
Technology-assisted tools including Internet-based social networks, distance learning, DVD-based content, and mobile applications may be useful elements of effective lifestyle modification to prevent diabetes.
Do Clinicians Tell Patients They Have Prehypertension?
TLDR
Few patients who probably have prehypertension are being told about it by clinicians, according to a cross-sectional study of adult patients visiting practices within the North Carolina Family Medicine Research Network in summer 2008.
Hypertension labeling and sense of well-being.
TLDR
It is suggested that the mislabeled group reported more depressive symptoms, lower present health, and a worsening of their health over the past five years are a result of people being falsely labeled as hypertensive.
Screening for type 2 diabetes.
TLDR
It will be important to use comprehensive cardiovascular disease modules that assess the conjoint influence of glucose and cardiovascular risk factor reduction, information on QOL, and refined economic evaluations using common outcome measures within economic studies to allow selection of the optimal approach within the financial and resource limitations of the health care system.
...
...