Predifferentiated embryonic stem cells promote functional recovery after spinal cord compressive injury.

@article{Marques2010PredifferentiatedES,
  title={Predifferentiated embryonic stem cells promote functional recovery after spinal cord compressive injury.},
  author={Suelen Adriani Marques and Fernanda Martins de Almeida and Aline Marie Fernandes and Cleide dos Santos Souza and Daniel Veloso Cadilhe and Stevens K. Rehen and Ana Maria Blanco Martinez},
  journal={Brain research},
  year={2010},
  volume={1349},
  pages={115-28}
}
We tested the effects of mouse embryonic stem cells (mES) grafts in mice spinal cord injury (SCI). Young adult female C57/Bl6 mice were subjected to laminectomy at T9 and 1-minute compression of the spinal cord with a vascular clip. Four groups were analyzed: laminectomy (Sham), injured (SCI), vehicle (DMEM), and mES-treated (EST). mES pre-differentiated with retinoic acid were injected (8 x 10(5) cells/2 microl) into the lesion epicenter, 10 min after SCI. Basso mouse scale (BMS) and Global… CONTINUE READING
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