Predictors of the short-term effectivenessresponder rate of Electroconvulsive therapy in depressive disorders – a population based study

Abstract

Background The aim of the present study is to investigate the effectiveness responder rate of Electroconvulsive therapy, ECT, in clinical routine work and to define clinical characteristics predictive of response to ECT. The main hypothesis is that the effectiveness responder rate of ECT might be lower in clinical routine than in controlled trials. Methods This is a population-based study of all patients (N= 990) treated with ECT for depressive disorders, between 2008-2010 in eight hospitals in Sweden. Patients with Clinical Global Impression-Improvement scores of 1 or 2 (much improved) within one week after ECT were considered responders to ECT. The predictive valuevalues of single clinical variables were tested by means of chi-squared tests and the relative importance was tested in a logistic regression analysis. Results The response responder rate was 80.1 %. A higher proportion of older patients (>50 years) responded (84.3% vs. 74.2%, p<0.001). Psychotically depressed patients responded better (88.9% vs. 81.5% for severely depressed and 72.8% for mildly depressed, p<0.001). There were no significant differences in response rate responder rates between patients suffering from bipolar, first or recurrent major depressive syndromes, or a depressive episode of schizoaffective disorder. Patients with personality disorder had a lower responseresponder rate (66.2% vs. 81.4%, p<0.001). Also, outpatients had a lower responseresponder rate (66.3%) compared to inpatients (83.4%, p<0.001). In the logistic regression analysis, inpatient status, psychotic symptoms and older age were independent factors associated with response to ECT. Conclusions AlsoThis study focuses exclusively on the short term responder rate with ECT in clinical routine work, the response rate to ECTpractice. Similarly to results form controlled trials a high responder rate is highreported. Older patients, more severely ill patients,

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@inproceedings{Nordenskjld2012PredictorsOT, title={Predictors of the short-term effectivenessresponder rate of Electroconvulsive therapy in depressive disorders – a population based study}, author={Axel Nordenskj{\"{o}ld and Lars von Knorring and Ingemar Engstr{\"{o}m}, year={2012} }