Predictors of seizure freedom in the surgical treatment of supratentorial cavernous malformations.

@article{Englot2011PredictorsOS,
  title={Predictors of seizure freedom in the surgical treatment of supratentorial cavernous malformations.},
  author={Dario J Englot and Seunggu J. Han and M T Lawton and Edward F. Chang},
  journal={Journal of neurosurgery},
  year={2011},
  volume={115 6},
  pages={1169-74}
}
OBJECT Seizures are the most common presenting symptom of supratentorial cerebral cavernous malformations (CCMs) and progress to medically refractory epilepsy in 40% of patients. Predictors of seizure freedom in the resection of CCMs are incompletely understood. METHODS The authors systematically reviewed the published literature on seizure freedom following the resection of supratentorial CCMs in patients presenting with seizures. Seizure outcomes were stratified across 12 potential… CONTINUE READING

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Additional prognostic indicators of a favorable outcome were a CCM size < 1.5 cm ( OR 15.4 , 95% CI 5.2 - 45.4 ) , the absence of multiple CCMs ( OR 2.02 , 95% CI 1.13 - 3.60 ) , medically controlled seizures ( OR 2.38 , 95% CI 1.29 - 4.39 ) , and the lack of secondarily generalized seizures ( OR 3.33 , 95% CI 2.09 - 5.30 ) .
Additional prognostic indicators of a favorable outcome were a CCM size < 1.5 cm ( OR 15.4 , 95% CI 5.2 - 45.4 ) , the absence of multiple CCMs ( OR 2.02 , 95% CI 1.13 - 3.60 ) , medically controlled seizures ( OR 2.38 , 95% CI 1.29 - 4.39 ) , and the lack of secondarily generalized seizures ( OR 3.33 , 95% CI 2.09 - 5.30 ) .
Additional prognostic indicators of a favorable outcome were a CCM size < 1.5 cm ( OR 15.4 , 95% CI 5.2 - 45.4 ) , the absence of multiple CCMs ( OR 2.02 , 95% CI 1.13 - 3.60 ) , medically controlled seizures ( OR 2.38 , 95% CI 1.29 - 4.39 ) , and the lack of secondarily generalized seizures ( OR 3.33 , 95% CI 2.09 - 5.30 ) .
Additional prognostic indicators of a favorable outcome were a CCM size < 1.5 cm ( OR 15.4 , 95% CI 5.2 - 45.4 ) , the absence of multiple CCMs ( OR 2.02 , 95% CI 1.13 - 3.60 ) , medically controlled seizures ( OR 2.38 , 95% CI 1.29 - 4.39 ) , and the lack of secondarily generalized seizures ( OR 3.33 , 95% CI 2.09 - 5.30 ) .
Additional prognostic indicators of a favorable outcome were a CCM size < 1.5 cm ( OR 15.4 , 95% CI 5.2 - 45.4 ) , the absence of multiple CCMs ( OR 2.02 , 95% CI 1.13 - 3.60 ) , medically controlled seizures ( OR 2.38 , 95% CI 1.29 - 4.39 ) , and the lack of secondarily generalized seizures ( OR 3.33 , 95% CI 2.09 - 5.30 ) .
Additional prognostic indicators of a favorable outcome were a CCM size < 1.5 cm ( OR 15.4 , 95% CI 5.2 - 45.4 ) , the absence of multiple CCMs ( OR 2.02 , 95% CI 1.13 - 3.60 ) , medically controlled seizures ( OR 2.38 , 95% CI 1.29 - 4.39 ) , and the lack of secondarily generalized seizures ( OR 3.33 , 95% CI 2.09 - 5.30 ) .
Additional prognostic indicators of a favorable outcome were a CCM size < 1.5 cm ( OR 15.4 , 95% CI 5.2 - 45.4 ) , the absence of multiple CCMs ( OR 2.02 , 95% CI 1.13 - 3.60 ) , medically controlled seizures ( OR 2.38 , 95% CI 1.29 - 4.39 ) , and the lack of secondarily generalized seizures ( OR 3.33 , 95% CI 2.09 - 5.30 ) .
Additional prognostic indicators of a favorable outcome were a CCM size < 1.5 cm ( OR 15.4 , 95% CI 5.2 - 45.4 ) , the absence of multiple CCMs ( OR 2.02 , 95% CI 1.13 - 3.60 ) , medically controlled seizures ( OR 2.38 , 95% CI 1.29 - 4.39 ) , and the lack of secondarily generalized seizures ( OR 3.33 , 95% CI 2.09 - 5.30 ) .
The authors systematically reviewed the published literature on seizure freedom following the resection of supratentorial CCMs in patients presenting with seizures .
The authors systematically reviewed the published literature on seizure freedom following the resection of supratentorial CCMs in patients presenting with seizures .
Predictors of seizure freedom in the surgical treatment of supratentorial cavernous malformations . OBJECT .
Seizures are the most common presenting symptom of supratentorial cerebral cavernous malformations ( CCMs ) and progress to medically refractory epilepsy in 40% of patients
A total of 1226 patients with supratentorial CCMs causing seizures were identified across 31 predominantly retrospective studies ; 361 patients had medically refractory epilepsy .
A total of 1226 patients with supratentorial CCMs causing seizures were identified across 31 predominantly retrospective studies ; 361 patients had medically refractory epilepsy .
Seizures are the most common presenting symptom of supratentorial cerebral cavernous malformations ( CCMs ) and progress to medically refractory epilepsy in 40% of patients
Seizures are the most common presenting symptom of supratentorial cerebral cavernous malformations ( CCMs ) and progress to medically refractory epilepsy in 40% of patients
While surgery should not be considered the first - line treatment for CCM - related epilepsy , it is important to understand the variables associated with seizure freedom in CCM resection given the considerable morbidity and diminished quality of life associated with epilepsy .
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