Predictors of pregnancy in microbicide trials.

  title={Predictors of pregnancy in microbicide trials.},
  author={Vera Halpern and Che-Chin Lie and Paul J. Feldblum and Lut van Damme},
  volume={83 5},
BACKGROUND High pregnancy rates undermine the conduct and interpretation of HIV prevention trials. We performed this analysis to identify baseline participant characteristics associated with increased risk of pregnancy in recent vaginal microbicide trials. STUDY DESIGN We analyzed the data from four recently completed Phase III trials of candidate microbicides for prevention of HIV infection. Cox proportional hazard models, stratified by site nested within study, were used to determine the… CONTINUE READING
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