Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data

@article{Tabrizi2013PredictorsOP,
  title={Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data},
  author={Sarah J Tabrizi and Rachael I. Scahill and Gail Owen and Alexandra Durr and Blair R. Leavitt and Raymund Roos and Beth Borowsky and Bernhard Landwehrmeyer and Chris Frost and Hans Johnson and David Craufurd and Ralf Reilmann and Julie C. Stout and Douglas R. Langbehn},
  journal={The Lancet Neurology},
  year={2013},
  volume={12},
  pages={637-649}
}
BACKGROUND TRACK-HD is a multinational prospective observational study of Huntington's disease (HD) that examines clinical and biological findings of disease progression in individuals with premanifest HD (preHD) and early-stage HD. We aimed to describe phenotypic changes in these participants over 36 months and identify baseline predictors of progression. METHODS Individuals without HD but carrying the mutant huntingtin gene (classed as preHD-A if ≥10·8 years and preHD-B if <10·8 years from… CONTINUE READING
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