Predictors of mortality in patients diagnosed with probable Alzheimer's disease

@article{Bowen1996PredictorsOM,
  title={Predictors of mortality in patients diagnosed with probable Alzheimer's disease},
  author={James D Bowen and A D Malter and Lianne Sheppard and Walter A Kukull and Wayne C. McCormick and Linda Teri and Eric B. Larson},
  journal={Neurology},
  year={1996},
  volume={47},
  pages={433 - 439}
}
Objective: We sought to identify factors associated with mortality in persons recently diagnosed with probable Alzheimer's disease (AD). Background: Predicting mortality in AD is needed both in patient care and public health planning. Previous studies have identified several factors which contribute to mortality in AD, but few longitudinal studies of population-based cohorts exist. Methods: In a longitudinal follow-up study 327 patients with newly diagnosed probable AD (mean Mini-Mental State… 

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References

SHOWING 1-10 OF 29 REFERENCES
Factors affecting course and survival in Alzheimer's disease. A 9-year longitudinal study.
TLDR
Severe aphasia appears to be the best predictor of death and unfavorable course in patients affected by probable AD, independent of age at onset or degree of dementia.
Survival of outpatients with Alzheimer-type dementia.
TLDR
Length of survival in patients with Alzheimer-type dementia is highly variable; severity of disease (not duration), the combination of wandering and falling, and behavioral problems are associated with shorter survival.
Predictors of survival in clinically diagnosed Alzheimer's disease and multi-infarct dementia.
TLDR
Since MID patients were younger at onset, MID patients had a lower life quotient than SDAT patients, and history of hypertension, elevated systolic blood pressure, lower scores on tests of Block Designs, and Logico-Grammatical Comprehension predicted shorter survival in SDAT.
Risk of death from Alzheimer's disease in a community population of older persons.
TLDR
Mortality for those with mild or moderate cognitive impairment and no evidence of cachexia was comparable to that of the unaffected, however, among those with probable Alzheimer's disease and either severe cognitive impairment or cachexia, the risk of death was substantially higher.
Survival and cause of death in Alzheimer's disease and multi‐infarct dementia
TLDR
In AD, the survival rate decreased with increasing severity of dementia, while in MID the mortality was the same regardless of the severity of the dementia, and a comparison of relative survival rates suggested that MID carries a less favorable survival prognosis than AD.
A controlled study of survival with dementia.
TLDR
It is concluded that dementia carries a significantly increased risk of mortality but that the survival of patients with dementia may be better than previous reports would suggest.
The accuracy of early diagnosis and predictors of death in Alzheimer's disease and vascular dementia — a follow‐up study
TLDR
The results underline the problems of early diagnosis of dementia according to DSM‐III criteria and show a high ischemia score and a low body mass index predicted death for both sexes but not for women.
Duration of survival in senile dementia
TLDR
The severity of behavioural and cognitive impairments predicted 1‐year survival after admission into a nursing home, as could be shown by multivariate analysis which corrected for the effects of age and sex.
Progression of Cognitive Impairment in Alzheimer's Disease
Change in cognitive function was assessed over 12 months in 110 patients over the age of 65 satisfying National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's
...
1
2
3
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