Predictors of insufficient amikacin peak concentration in critically ill patients receiving a 25 mg/kg total body weight regimen

@article{Montmollin2014PredictorsOI,
  title={Predictors of insufficient amikacin peak concentration in critically ill patients receiving a 25 mg/kg total body weight regimen},
  author={Etienne de Montmollin and Lila Bouadma and Nathalie Gault and Bruno H Mourvillier and Eric Mariotte and Sarah Chemam and Laurent Massias and Emmanuelle Papy and Florence Tubach and Michel Wolff and Romain Sonneville},
  journal={Intensive Care Medicine},
  year={2014},
  volume={40},
  pages={998-1005}
}
Amikacin requires pharmacodynamic targets of peak serum concentration (C max) of 8–10 times the minimal inhibitory concentration, corresponding to a target C max of 60–80 mg/L for the less susceptible bacteria. Even with new dosing regimens of 25 mg/kg, 30 % of patients do not meet the pharmacodynamic target. We aimed to identify predictive factors for insufficient C max in a population of critically ill patients. Prospective observational monocentric study of patients admitted to a general ICU… CONTINUE READING

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