Predictors of high vancomycin MIC values among patients with methicillin-resistant Staphylococcus aureus bacteraemia.

@article{Lodise2008PredictorsOH,
  title={Predictors of high vancomycin MIC values among patients with methicillin-resistant Staphylococcus aureus bacteraemia.},
  author={Thomas P. Lodise and Christopher D. Miller and Jeffrey Graves and Ann Evans and Eileen M Graffunder and Megan R Helmecke and Kathleen Stellrecht},
  journal={The Journal of antimicrobial chemotherapy},
  year={2008},
  volume={62 5},
  pages={1138-41}
}
BACKGROUND Recent evidence suggests that vancomycin demonstrates reduced activity against methicillin-resistant Staphylococcus aureus (MRSA) infections when vancomycin MIC values are at the high end of the susceptibility range (> or = 1.5 mg/L). However, scant research exists on factors predictive of high vancomycin MICs (> or = 1.5 mg/L) among MRSA bacteraemic patients. Empirical therapy decisions would greatly benefit from such information. OBJECTIVES To identify the parameters predictive… CONTINUE READING

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