Predictors of health‐related quality of life and costs in adults with epilepsy: A systematic review

  title={Predictors of health‐related quality of life and costs in adults with epilepsy: A systematic review},
  author={Rod S. Taylor and Josemir W Sander and Rebecca J. Taylor and Gus Baker},
Purpose:  Given the high burden of epilepsy on both health‐related quality of life (HRQoL) and costs, identification of factors that are predictive of either reduced HRQoL or increased expenditure is central to the better future targeting and optimization of existing and emerging interventions and management strategies for epilepsy. 

Determinants of health‐related quality of life in pharmacoresistant epilepsy: Results from a large multicenter study of consecutively enrolled patients using validated quantitative assessments

Purpose:  To evaluate the relative contribution of demographic and epilepsy‐related variables, depressive symptoms, and adverse effects (AEs) of antiepileptic drugs (AEDs) to health‐related quality

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To investigate prospectively the independent predictors of a minimum clinically important change (MCIC) in quality of life (QOL) after anterior temporal lobectomy (ATL) for drug‐resistant mesial

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Multicenter, cross‐sectional study of the costs of illness and cost‐driving factors in adult patients with epilepsy

This study was undertaken to quantify epilepsy‐related costs of illness (COI) in Germany and identify cost‐driving factors.

Quality of life in young adults who underwent resective surgery for epilepsy in childhood

Quality of life in young adults who had undergone epilepsy surgery before the age of 16 years was investigated, and the contribution to QOL of seizure status in the prior year, sex, number of antiepileptic drugs, and mood were evaluated.

Cost‐effectiveness analysis of epilepsy surgery in a controlled cohort of adult patients with intractable partial epilepsy: A 5‐year follow‐up study

Compared cost‐effectiveness between resective surgery and medical therapy in a controlled cohort of adult patients with partial intractable epilepsy is compared.

Impact of somatic comorbidities on quality of life of patients living with epilepsy in Sagamu, Nigeria

The main objective of this study was to determine the frequencies of somatic comorbidities in people with epilepsy (PWE), and compared quality of life of two groups of PWE: Those with somatic COMORbidities and those without.

Long‐term reduction of health care costs and utilization after epilepsy surgery

To assess long‐term direct medical costs, health care utilization, and mortality following resective surgery in persons with uncontrolled epilepsy, a large number of cases are classified as having uncontrolled epilepsy.

Comorbidities in patients with epilepsy: Frequency, mechanisms and effects on long‐term outcome

The association of endocrine/metabolic, psychiatric, and respiratory comorbidities with epilepsy prognosis was confirmed by multivariable analysis adjusted for the main demographic and clinical variables, with patients with these comorbridities showing a lower probability of achieving remission.



Health‐related quality of life over time since resective epilepsy surgery

Health‐related quality of life (HRQOL) improves after resective epilepsy surgery, but data are limited to short follow‐up in mostly retrospective reports, with minimal consideration of other

The Relative Impact of Anxiety, Depression, and Clinical Seizure Features on Health‐related Quality of Life in Epilepsy

Summary:  Purpose: To determine the independent effects of depression and anxiety on health‐related quality of life (HRQOL) in epilepsy as well as the relative explanatory power of psychiatric

Relationships Between Seizure Severity and Health‐Related Quality of Life in Refractory Localization‐Related Epilepsy

Evaluation of relationships between self‐report measures of seizure severity and health‐related quality of life (HRQOL) in people with refractory localization‐related epilepsy finds no clear relationship between these measures and well-being.

Social Functioning, Psychological Functioning, and Quality of Life in Epilepsy

A series of already existing generic and disease‐specific health status measures were used and considered as determinants of people's QoL, whereasQoL itself was conceived as a general “value judgment” about one's life.

Determinants of quality of life in people with epilepsy.

Relationship Between Seizure Frequency and Costs and Quality of Life of Outpatients with Partial Epilepsy in France, Germany, and the United Kingdom

Summary: Purpose: The relationship between seizure frequency and both health care costs and quality of life (QOL) was investigated in a retrospective, cross‐sectional, multicenter study in France,

Quality of Life of People with Epilepsy: A European Study

The aim of this study was to collect data from as many countries as possible to study the impact of epilepsy and its treatment on people with epilepsy in Europe.

Quality‐of‐Life and Behavioral Outcome Measures in Randomized Controlled Trials of Antiepileptic Drugs: A Systematic Review of Methodology and Reporting Standards

The methodology and use of quality‐of‐life and behavioral measures used in randomized controlled trials (RCTs) of antiepileptic drugs in patients with epilepsy are reviewed.

Epilepsy in Estonia: A Quality‐of‐Life Study

To study the impact of epilepsy and its treatment on people with epilepsy in Estonia and to analyze how it is affected by the characteristics of epilepsy.

Factors affecting the quality of life in patients with epilepsy in Seoul, South Korea

The level of, and factors affecting the quality of life in patients with epilepsy may be different in Korea where social prejudice toward them is still pronounced and these issues have not yet been addressed properly.