Predictors of global methylation levels in blood DNA of healthy subjects: a combined analysis.

  title={Predictors of global methylation levels in blood DNA of healthy subjects: a combined analysis.},
  author={Zhong-zheng Zhu and Lifang Hou and Valentina Bollati and Letizia Tarantini and Barbara Marinelli and Laura Cantone and Allen S. Yang and Pantel Vokonas and Jolanta Lissowska and Silvia Fustinoni and Angela Cecilia Pesatori and Matteo Bonzini and Pietro Apostoli and Giovanni Costa and Pier Alberto Bertazzi and W H Chow and Joel Schwartz and Andrea A. Baccarelli},
  journal={International journal of epidemiology},
  volume={41 1},
BACKGROUND Estimates of global DNA methylation from repetitive DNA elements, such as Alu and LINE-1, have been increasingly used in epidemiological investigations because of their relative low-cost, high-throughput and quantitative results. Nevertheless, determinants of these methylation measures in healthy individuals are still largely unknown. The aim of this study was to examine whether age, gender, smoking habits, alcohol drinking and body mass index (BMI) are associated with Alu or LINE-1… CONTINUE READING
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