Predictors of ertapenem therapeutic efficacy in the treatment of urinary tract infections (UTIs) in hospitalized adults: the importance of renal insufficiency and urinary pH

@article{Cunha2016PredictorsOE,
  title={Predictors of ertapenem therapeutic efficacy in the treatment of urinary tract infections (UTIs) in hospitalized adults: the importance of renal insufficiency and urinary pH},
  author={Burke A. Cunha and J. Giuga and Steve Gerson},
  journal={European Journal of Clinical Microbiology \& Infectious Diseases},
  year={2016},
  volume={35},
  pages={673-679}
}
In hospitalized adults acute uncomplicated cystitis (AUC) and catheter associated bacteriuria (CAB) may be treated with oral antibiotics. With AUC or CAB due to extended spectrum ß-lactamase (ESBL) + Gram negative bacilli (GNB) physicians often use intravenous therapy, e.g., ertapenem. We reviewed our recent experience in hospitalized adults with AUC and CAB treated with ertapenem. Therapeutic efficacy of ertapenem was assessed by decreased pyuria/bacteriuria, and elimination of the uropathogen… Expand
An infectious disease and pharmacokinetic perspective on oral antibiotic treatment of uncomplicated urinary tract infections due to multidrug-resistant Gram-negative uropathogens: the importance of urinary antibiotic concentrations and urinary pH
  • B. Cunha
  • Medicine
  • European Journal of Clinical Microbiology & Infectious Diseases
  • 2016
TLDR
The importance of urinary antibiotic concentrations in determining the urinary spectrum of oral antibiotics and the effect of urinary pH are discussed as determinants of therapeutic efficacy. Expand

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