Predictors of decline in CD4 lymphocytes in a cohort of homosexual men infected with human immunodeficiency virus.

@article{Muoz1988PredictorsOD,
  title={Predictors of decline in CD4 lymphocytes in a cohort of homosexual men infected with human immunodeficiency virus.},
  author={Alvaro Muňoz and Vincent Carey and Alfred J. Saah and John P. Phair and Lawrence A. Kingsley and John L. Fahey and Harold M Ginzburg and B. Frank Polk},
  journal={Journal of acquired immune deficiency syndromes},
  year={1988},
  volume={1 4},
  pages={396-404}
}
Longitudinal data on four visits scheduled at 6 month intervals were available on a cohort of 1,827 homosexual men who were human immunodeficiency virus (HIV) seropositive at entry. To identify predictors of the rate of decline of CD4 T-lymphocytes, we used an autoregressive model that relates CD4 counts to predictor variables, while adjusting for previous CD4 counts. Significant predictors of steeper decline of CD4 counts were high CD8 count, low hemoglobin, low platelets, high serum IgA, high… CONTINUE READING
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