Predictors of clozapine response in schizophrenia.

  title={Predictors of clozapine response in schizophrenia.},
  author={David Pickar and Richard R. Owen and Robert E. Litman and John K. Hsiao and T P Su},
  journal={The Journal of clinical psychiatry},
  volume={55 Suppl B},
The introduction of the atypical neuroleptic, clozapine, has had widespread influence not only on the treatment of the seriously mentally ill patient, but also on new drug development and on hypotheses of the pathophysiology of schizophrenia. While clozapine differs from traditional neuroleptics in its lack of extrapyramidal side effects (EPS), it also is distinct in its profile of neurotransmitter receptor affinities. In our work examining the clinical and biological effects of clozapine in… CONTINUE READING

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