Predictors of an acute antidepressant response to fluoxetine and sertraline.

  title={Predictors of an acute antidepressant response to fluoxetine and sertraline.},
  author={M F. Flament and Roger M. Lane and R Zhu and Zhang Ying},
  journal={International clinical psychopharmacology},
  volume={14 5},
Sertraline and fluoxetine have different pharmacologic and pharmacokinetic profiles which may be of clinical relevance in the determination of response in different subtypes of depression. A randomized, double-blind, 6-week study comparing sertraline (50-100 mg/day) with fluoxetine (20-40 mg/day) in 286 outpatients with major depression, who had demonstrated comparable efficacy and tolerability for the two drugs, was analysed by subgroups of patients at baseline with melancholia, severe… CONTINUE READING
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