Predictors of Outcome in an Open Label, Therapeutic Trial of High-Dose Omeprazole in Laryngitis

@article{Williams2004PredictorsOO,
  title={Predictors of Outcome in an Open Label, Therapeutic Trial of High-Dose Omeprazole in Laryngitis},
  author={Rohan Benjamin Williams and Michal Szczesniak and J Maclean and Helen Mary Brake and Ian E. Cole and Ian Cook},
  journal={American Journal of Gastroenterology},
  year={2004},
  volume={99},
  pages={777-785}
}
BACKGROUND:Gastroesophageal reflux is implicated in some cases of laryngitis. There are no established predictors of response to acid suppression therapy in suspected reflux laryngitis.AIM:In a population with laryngitis, the aim is to determine whether (a) omeprazole 20 mg tds (3 months) improves symptoms and laryngitis, and (b) the outcome in response to potent acid suppression can be predicted by esophageal and/or pharyngeal parameters during ambulatory pH monitoring or by other pretreatment… CONTINUE READING
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