Predictors of CNS injury as measured by proton magnetic resonance spectroscopy in the setting of chronic HIV infection and CART

@article{Harezlak2014PredictorsOC,
  title={Predictors of CNS injury as measured by proton magnetic resonance spectroscopy in the setting of chronic HIV infection and CART},
  author={Jaroslaw Harezlak and Ron Cohen and Assawin Gongvatana and Michael Taylor and S. Buchthal and Giovanni Schifitto and Jianhui Zhong and Eric S Daar and Jeffry R. Alger and Mark Brown and Elyse J. Singer and Thomas B. Campbell and Deborah Mcmahon and Y. T. So and Constantin T. Yiannoutsos and Bradford Navia},
  journal={Journal of NeuroVirology},
  year={2014},
  volume={20},
  pages={294-303}
}
The reasons for persistent brain dysfunction in chronically HIV-infected persons on stable combined antiretroviral therapies (CART) remain unclear. Host and viral factors along with their interactions were examined in 260 HIV-infected subjects who underwent magnetic resonance spectroscopy (MRS). Metabolite concentrations (NAA/Cr, Cho/Cr, MI/Cr, and Glx/Cr) were measured in the basal ganglia, the frontal white matter, and gray matter, and the best predictive models were selected using a… CONTINUE READING

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