Predictive value of interferon-γ release assays and tuberculin skin testing for progression from latent TB infection to disease state: a meta-analysis.

@article{Diel2012PredictiveVO,
  title={Predictive value of interferon-γ release assays and tuberculin skin testing for progression from latent TB infection to disease state: a meta-analysis.},
  author={Roland Diel and Robert Loddenkemper and Albert Nienhaus},
  journal={Chest},
  year={2012},
  volume={142 1},
  pages={63-75}
}
BACKGROUND Given the current lack of effective vaccines against TB, the accuracy of screening tests for determining or excluding latent TB infection (LTBI) is decisive in effective TB control. This meta-analysis critically appraises studies investigating the positive and the negative predictive value (PPV and NPV, respectively) from a test-determined LTBI state for progression to active TB of interferon-γ release assays (IGRAs) and the tuberculin skin test (TST). METHODS We searched MEDLINE… CONTINUE READING