Predictive value of factor V Leiden and prothrombin G20210A in adults with venous thromboembolism and in family members of those with a mutation: a systematic review.

@article{Segal2009PredictiveVO,
  title={Predictive value of factor V Leiden and prothrombin G20210A in adults with venous thromboembolism and in family members of those with a mutation: a systematic review.},
  author={J Bradley Segal and Daniel Brotman and Alejandro J Necochea and Ashkan Emadi and Lipika Samal and L. M. Kinnier Wilson and Matthew T. Crim and Eric B. Bass},
  journal={JAMA},
  year={2009},
  volume={301 23},
  pages={2472-85}
}
CONTEXT Testing for genetic risks for venous thromboembolism (VTE) is common, but the safety and utility of such testing need review. OBJECTIVES To define rates of recurrent VTE among adults with VTE with a factor V Leiden (FVL) or prothrombin G20210A mutation compared with those without such mutations; to define rates of VTE among family members of adults with a FVL or prothrombin G20210A mutation according to presence or absence of a mutation; and to assess whether testing adults with VTE… CONTINUE READING

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