Predictive value of early weight loss in obesity management with orlistat: an evidence-based assessment of prescribing guidelines

@article{Rissanen2003PredictiveVO,
  title={Predictive value of early weight loss in obesity management with orlistat: an evidence-based assessment of prescribing guidelines},
  author={Aila M. Rissanen and Mei Li Lean and Stephan R{\"o}ssner and Karen R. Segal and Lars V Sj{\"o}str{\"o}m},
  journal={International Journal of Obesity},
  year={2003},
  volume={27},
  pages={103-109}
}
OBJECTIVE: To assess the clinical usefulness of published guidelines for the use of orlistat, by studying whether weight loss ≥2.5 kg during a 4 week dietary lead-in period, and weight losses of ≥5% after 12 weeks and ≥10% after 6 months of drug therapy predict weight loss and risk factor changes after 2 years.DESIGN: A retrospective analysis of pooled data from 2 multicentre, randomised, placebo-controlled clinical trials with similar design.SETTING: Twenty-nine centres throughout Europe… CONTINUE READING
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