Predictive value of carbohydrate antigen 19-9 in pancreatic cancer treated with radiochemotherapy.

Abstract

PURPOSE To determine the predictive value of carbohydrate antigen (CA) 19-9 in pancreatic cancer treated with radiochemotherapy. METHODS AND MATERIALS Ninety-five patients with locally advanced unresectable adenocarcinoma of the pancreas were treated with hyperfractionated accelerated radiotherapy to a total dose of 44.8 Gy combined with 5-fluorouracil and folinic acid. CA 19-9 was measured before therapy, each week during therapy, and every 4 weeks during the follow-up period. RESULTS The median CA 19-9 before treatment was 420 U/mL; in the responder group it was 117 U/mL, and in the nonresponder group it was 806 U/mL. Patients with a pretreatment CA 19-9 less than the median had not only a significantly better tumor response (45.8%) but also a better survival prognosis (median survival 12.3 months) than those with a level higher than the median (tumor response 12.8%; median survival 7.1 months). The posttreatment median CA 19-9 for all patients also exhibited prognostic significance. The median survival of patients with a CA 19-9 level lower than the posttreatment median of 293 U/mL was 13.5 months, compared with 7.2 months for those with a CA 19-9 level greater than the median. To detect recurrent disease during follow-up, the sensitivity of CA 19-9 was 100% and the specificity 88%. CONCLUSION Our results indicate that CA 19-9 is of predictive value for prognosis, response, and detecting recurrence of pancreatic cancer in patients undergoing combined radiochemotherapy. Therefore, we recommend the routine implementation of CA 19-9 observation during the clinical course of treatment for patients with pancreatic cancer undergoing radiochemotherapy.

Statistics

050100'05'06'07'08'09'10'11'12'13'14'15'16'17
Citations per Year

286 Citations

Semantic Scholar estimates that this publication has received between 66 and 788 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Micke2003PredictiveVO, title={Predictive value of carbohydrate antigen 19-9 in pancreatic cancer treated with radiochemotherapy.}, author={Oliver Micke and Frank Bruns and Rene Kurowski and Eckehard Horst and Alexander F deVries and John W Hausler and Normann Willich and Ulrich Sch{\"a}fer}, journal={International journal of radiation oncology, biology, physics}, year={2003}, volume={57 1}, pages={90-7} }