Predictive value of antinuclear autoantibodies: the lessons of the systemic sclerosis autoantibodies.

@article{Koenig2008PredictiveVO,
  title={Predictive value of antinuclear autoantibodies: the lessons of the systemic sclerosis autoantibodies.},
  author={M. E. D. Koenig and M{\'e}lanie Dieud{\'e} and Jean-Luc Sen{\'e}cal},
  journal={Autoimmunity reviews},
  year={2008},
  volume={7 8},
  pages={588-93}
}
Physicians who provide care to patients with systemic sclerosis (SSc, scleroderma) ask themselves several questions: Is SSc the correct diagnosis? Can the disease course be predicted? Is there a greater risk for involvement of certain organs? Can the vital prognosis be predicted? In this brief review, we answer these questions by excerpting data from the literature focused on the 4 major SSc specific autoantibodies (aAbs) to nuclear autoantigens (ANAs): anti-centromere (anti-CENP-B), anti-Th/To… CONTINUE READING

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