Predictive value of APOE-ε4 allele for progression from MCI to AD-type dementia: a meta-analysis.

@article{EliasSonnenschein2011PredictiveVO,
  title={Predictive value of APOE-ε4 allele for progression from MCI to AD-type dementia: a meta-analysis.},
  author={Lyzel S. Elias-Sonnenschein and Wolfgang Viechtbauer and Inez H. G. B. Ramakers and Frans R. J. Verhey and Pieter Jelle Visser},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={2011},
  volume={82 10},
  pages={1149-56}
}
BACKGROUND The identification of subjects with mild cognitive impairment (MCI) at high risk for Alzheimer's disease (AD) is important for prognosis and early intervention. The APOE-ε4 allele is the strongest known genetic risk factor for AD. The authors performed a meta-analysis to establish the predictive accuracy of the APOE-ε4 allele for progression from MCI to AD-type dementia. METHODS The authors included 35 prospective cohort studies of subjects with MCI, including 6095 subjects, of… CONTINUE READING
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