Predictive validity of the extinction/reinstatement model of drug craving

Abstract

 The effects of chronic desmethylimipramine (DMI) treatment on measures of incentive motivation for cocaine were assessed in order to investigate the predictive validity of the extinction/reinstatement model of drug craving. Rats were trained to respond for cocaine infusions (0.75 mg/kg per 0.1 ml IV) or received yoked-saline infusions during daily 3-h… (More)
DOI: 10.1007/s002130050496

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