Predictive model of thrombospondin-1 and vascular endothelial growth factor in breast tumor tissue

@inproceedings{Rohrs2016PredictiveMO,
  title={Predictive model of thrombospondin-1 and vascular endothelial growth factor in breast tumor tissue},
  author={Jennifer A. Rohrs and Christopher D Sulistio and Stacey D. Finley},
  booktitle={npj Systems Biology and Applications},
  year={2016}
}
Angiogenesis, the formation of new blood capillaries from pre-existing vessels, is a hallmark of cancer. Thus far, strategies for reducing tumor angiogenesis have focused on inhibiting pro-angiogenic factors, and less is known about the therapeutic effects of mimicking the actions of angiogenesis inhibitors. Thrombospondin-1 (TSP1) is an important endogenous inhibitor of angiogenesis that has been investigated as an anti-angiogenic agent. TSP1 impedes the growth of new blood vessels in many… CONTINUE READING
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