Predictive model accuracy in estimating last Δ9-tetrahydrocannabinol (THC) intake from plasma and whole blood cannabinoid concentrations in chronic, daily cannabis smokers administered subchronic oral THC.

@article{Karschnera2012PredictiveMA,
  title={Predictive model accuracy in estimating last Δ9-tetrahydrocannabinol (THC) intake from plasma and whole blood cannabinoid concentrations in chronic, daily cannabis smokers administered subchronic oral THC.},
  author={L. Karschnera and David M. Schwopea and Eugene W. Schwilkea and Robert S. Goodwina and Deanna L. Kellyb and A. Gorelicka and Marilyn A. Huestisa},
  journal={Drug and alcohol dependence},
  year={2012},
  volume={125 3},
  pages={
          313-9
        }
}
BACKGROUND Determining time since last cannabis/Δ9-tetrahydrocannabinol (THC) exposure is important in clinical, workplace, and forensic settings. Mathematical models calculating time of last exposure from whole blood concentrations typically employ a theoretical 0.5 whole blood-to-plasma (WB/P) ratio. No studies previously evaluated predictive models utilizing empirically-derived WB/P ratios, or whole blood cannabinoid pharmacokinetics after subchronic THC dosing. METHODS Ten male chronic… CONTINUE READING

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