Predictive in vivo animal models and translation to clinical trials.

@article{Cook2012PredictiveIV,
  title={Predictive in vivo animal models and translation to clinical trials.},
  author={Natalie Cook and D. Jodrell and D. Tuveson},
  journal={Drug discovery today},
  year={2012},
  volume={17 5-6},
  pages={
          253-60
        }
}
  • Natalie Cook, D. Jodrell, D. Tuveson
  • Published 2012
  • Medicine, Biology
  • Drug discovery today
  • Vast resources are expended during the development of new cancer therapeutics, and selection of optimal in vivo models should improve this process. Genetically engineered mouse models (GEMM) of cancer have progressively improved in technical sophistication and, accurately recapitulating the human cognate condition, have had a measureable impact on our knowledge of tumourigenesis. However, the application of GEMMs to facilitate the development of innovative therapeutic and diagnostic approaches… CONTINUE READING

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