Predictive gene signature in MAGE-A3 antigen-specific cancer immunotherapy.

@article{UlloaMontoya2013PredictiveGS,
  title={Predictive gene signature in MAGE-A3 antigen-specific cancer immunotherapy.},
  author={Fernando Ulloa-Montoya and Jamila Louahed and Benjamin Dizier and Olivier Gruselle and Bart Spiessens and Fr{\'e}d{\'e}ric F. Lehmann and Stefan Suciu and Wim H. J. Kruit and A. M. M. Eggermont and Johan Vansteenkiste and Vincent G Brichard},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2013},
  volume={31 19},
  pages={2388-95}
}
PURPOSE To detect a pretreatment gene expression signature (GS) predictive of response to MAGE-A3 immunotherapeutic in patients with metastatic melanoma and to investigate its applicability in a different cancer setting (adjuvant therapy of resected early-stage non-small-cell lung cancer [NSCLC]). PATIENTS AND METHODS Patients were participants in two phase II studies of the recombinant MAGE-A3 antigen combined with an immunostimulant (AS15 or AS02B). mRNA from melanoma biopsies was analyzed… CONTINUE READING
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