Predictive factors for open-angle glaucoma among patients with ocular hypertension in the European Glaucoma Prevention Study.

@article{Miglior2007PredictiveFF,
  title={Predictive factors for open-angle glaucoma among patients with ocular hypertension in the European Glaucoma Prevention Study.},
  author={S. Miglior and N. Pfeiffer and V. Torri and T. Zeyen and J. Cunha-Vaz and I. Adamsons},
  journal={Ophthalmology},
  year={2007},
  volume={114 1},
  pages={
          3-9
        }
}
OBJECTIVE To evaluate the predictive factors of open-angle glaucoma (OAG) in patients affected by ocular hypertension enrolled in the European Glaucoma Prevention Study (EGPS). DESIGN Randomized, double-masked, controlled clinical trial. PARTICIPANTS One thousand seventy-seven patients, > or =30 years old, were enrolled at 18 European centers. The patients met inclusion criteria: intraocular pressure, 22 to 29 mmHg; 2 normal and reliable visual fields (VFs) (on the basis of mean deviation… Expand
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References

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Results of the European Glaucoma Prevention Study.
TLDR
The EGPS failed to detect a statistically significant difference between medical therapy and placebo in reducing the incidence of POAG among a large population of OHT patients at moderate risk for developing POAG, because placebo also significantly and consistently lowered IOP. Expand
The European glaucoma prevention study design and baseline description of the participants.
TLDR
The European Glaucoma Prevention Study should be able to better address the clinical question of whether pharmacological reduction of IOP (by means of dorzolamide) in ocular hypertension patients at moderate risk for developing primary open-angle glaucomA effectively lowers the incidence ofPrimary open-angles glaucolysis. Expand
The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma.
TLDR
Baseline age, vertical and horizontal cup-disc ratio, pattern standard deviation, and intraocular pressure were good predictors for the onset of POAG in the OHTS and central corneal thickness was found to be a powerful predictor for the development ofPOAG. Expand
A Long-Term Prospective Study of Risk Factors for Glaucomatous Visual Field Loss in Patients With Ocular Hypertension
TLDR
Patients with ocular hypertension were at higher risk for developing glaucomatous visual field loss if discs were suspect, if IOP was high, and if the patient was older in age. Expand
Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial.
TLDR
The first adequately powered randomized trial with an untreated control arm to evaluate the effects of IOP reduction in patients with open-angle glaucoma who have elevated and normal IOP showed considerable beneficial effects of treatment that significantly delayed progression. Expand
Factors for glaucoma progression and the effect of treatment: the early manifest glaucoma trial.
TLDR
Patients treated in the EMGT had half of the progression risk of control patients, including the effect of EMGT treatment, and the magnitude of initial IOP reduction was a major factor influencing outcome. Expand
Vascular risk factors for primary open angle glaucoma: the Egna-Neumarkt Study.
TLDR
The data are in line with those reported in other recent epidemiologic studies and show that reduced diastolic perfusion pressure is an important risk factor for primary open-angle glaucoma. Expand
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TLDR
The presence of open-angle glaucoma is increased in people with older-onset diabetes, and rates of persons meeting optic disc, visual field, and intraocular pressure criteria for definite glauca were more common than in those without diabetes. Expand
The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma.
TLDR
Topical ocular hypotensive medication was effective in delaying or preventing the onset of POAG in individuals with elevated IOP, and clinicians should consider initiating treatment for individuals with ocular hypertension who are at moderate or high risk for developing POAG. Expand
Primary open-angle glaucoma, intraocular pressure, and diabetes mellitus in the general elderly population. The Rotterdam Study.
TLDR
Newly diagnosed diabetes mellitus and high levels of blood glucose are associated with elevated IOP and high-tension glaucoma. Expand
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