Predictive efficacy of SCID-hu mouse models for treatment of human cytomegalovirus infections.

@article{Kern2001PredictiveEO,
  title={Predictive efficacy of SCID-hu mouse models for treatment of human cytomegalovirus infections.},
  author={Earl R. Kern and Rachel J Rybak and Caroll B. Hartline and Deborah J Bidanset},
  journal={Antiviral chemistry & chemotherapy},
  year={2001},
  volume={12 Suppl 1},
  pages={149-56}
}
There are few animal models to evaluate the in vivo activity of new compounds against human cytomegalovirus (HCMV) infections, as virus replication is largely limited to human cells. In our studies, we have utilized SCID mice implanted with human tissue (SCID-hu) and inoculated with HCMV as models for infections of the eye or visceral organs in an immunocompromised host. For the ocular model, fetal human retinal tissue was implanted in the anterior chamber of the SCID mouse eye and inoculated 6… CONTINUE READING
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