Predictive design of mRNA translation initiation region to control prokaryotic translation efficiency.

@article{Seo2013PredictiveDO,
  title={Predictive design of mRNA translation initiation region to control prokaryotic translation efficiency.},
  author={Sang Woo Seo and Jae-Seong Yang and Inhae Kim and Jina Yang and Byung Eun Min and Sanguk Kim and Gyoo Yeol Jung},
  journal={Metabolic engineering},
  year={2013},
  volume={15},
  pages={
          67-74
        }
}
Precise prediction of prokaryotic translation efficiency can provide valuable information for optimizing bacterial host for the production of biochemical compounds or recombinant proteins. However, dynamic changes in mRNA folding throughout translation make it difficult to assess translation efficiency. Here, we systematically determined the universal folding regions that significantly affect the efficiency of translation in Escherichia coli. By assessing the specific regions for mRNA folding… CONTINUE READING

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