Predictive biomarkers of chemotherapy efficacy in colorectal cancer: results from the UK MRC FOCUS trial.

@article{Braun2008PredictiveBO,
  title={Predictive biomarkers of chemotherapy efficacy in colorectal cancer: results from the UK MRC FOCUS trial.},
  author={Michael C Braun and Susan D Richman and Philip Quirke and Catherine L Daly and Julian W. Adlard and Faye Elliott and Jennifer H. Barrett and Peter Selby and Angela Mary Meade and Richard Stephens and Mahesh K B Parmar and Matthew T. Seymour},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2008},
  volume={26 16},
  pages={2690-8}
}
PURPOSE Candidate predictive biomarkers for irinotecan and oxaliplatin were assessed in 1,628 patients in Fluorouracil, Oxaliplatin, CPT-11: Use and Sequencing (FOCUS), a large randomized trial of fluorouracil alone compared with fluorouracil and irinotecan and compared with fluorouracil and oxaliplatin in advanced colorectal cancer. METHODS The candidate biomarkers were: tumor immunohistochemistry for MLH1/MSH2, p53, topoisomerase-1 (Topo1), excision repair cross-complementing gene 1 (ERCC1… CONTINUE READING
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