Predictive behavior within microbial genetic networks.

@article{Tagkopoulos2008PredictiveBW,
  title={Predictive behavior within microbial genetic networks.},
  author={Ilias Tagkopoulos and Yir-Chung Liu and Saeed Tavazoie},
  journal={Science},
  year={2008},
  volume={320 5881},
  pages={1313-7}
}
The homeostatic framework has dominated our understanding of cellular physiology. We question whether homeostasis alone adequately explains microbial responses to environmental stimuli, and explore the capacity of intracellular networks for predictive behavior in a fashion similar to metazoan nervous systems. We show that in silico biochemical networks, evolving randomly under precisely defined complex habitats, capture the dynamical, multidimensional structure of diverse environments by… CONTINUE READING
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