Predictive Potential of Flux Balance Analysis of Saccharomyces cerevisiae Using as Optimization Function Combinations of Cell Compartmental Objectives

@inproceedings{Snchez2012PredictivePO,
  title={Predictive Potential of Flux Balance Analysis of Saccharomyces cerevisiae Using as Optimization Function Combinations of Cell Compartmental Objectives},
  author={Carlos Eduardo Garc{\'i}a S{\'a}nchez and C{\'e}sar Augusto Vargas Garc{\'i}a and Rodrigo Gonzalo Torres S{\'a}ez},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND The main objective of flux balance analysis (FBA) is to obtain quantitative predictions of metabolic fluxes of an organism, and it is necessary to use an appropriate objective function to guarantee a good estimation of those fluxes. METHODOLOGY In this study, the predictive performance of FBA was evaluated, using objective functions arising from the linear combination of different cellular objectives. This approach is most suitable for eukaryotic cells, owing to their multiplicity… CONTINUE READING
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