Predictive Performance of a Semiparametric Method to Estimate Population Pharmacokinetic Parameters Using NONMEM

@article{Bressolle1998PredictivePO,
  title={Predictive Performance of a Semiparametric Method to Estimate Population Pharmacokinetic Parameters Using NONMEM},
  author={Françoise Bressolle and Roberto Gomeni},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
  year={1998},
  volume={26},
  pages={349-361}
}
Routine clinical pharmacokinetic (PK) data collected from patients receiving inulin were analyzed to estimate population PK parameters; 560 plasma concentration determinations for inulin were obtained from 90 patients. The data were analyzed using NONMEM. The population PK parameters were estimated using a Constrained Longitudinal Splines (CLS) semiparametric approach and a first-order conditional method (FOCE). The mean posterior individual clearance values were 7.73 L/hr using both parametric… CONTINUE READING