Predictive Modeling of Signaling Crosstalk during C. elegans Vulval Development

  title={Predictive Modeling of Signaling Crosstalk during C. elegans Vulval Development},
  author={Jasmin Fisher and Nir Piterman and Alex Hajnal and Thomas A. Henzinger},
  journal={PLoS Computational Biology},
  pages={1675 - 1682}
Caenorhabditis elegans vulval development provides an important paradigm for studying the process of cell fate determination and pattern formation during animal development. Although many genes controlling vulval cell fate specification have been identified, how they orchestrate themselves to generate a robust and invariant pattern of cell fates is not yet completely understood. Here, we have developed a dynamic computational model incorporating the current mechanistic understanding of gene… CONTINUE READING
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Predictive modeling of signaling crosstalk during C . elegans vulval development

J Fisher, T A. Henzinger
PLoS Comput . Biol . • 2007

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Proceedings of the 2006 Winter Simulation Conference • 2006
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Computational insights into Caenorhabditis elegans vulval development.

Proceedings of the National Academy of Sciences of the United States of America • 2005
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