Predictive Integration of Gene Ontology-Driven Similarity and Functional Interactions

@article{Azuaje2006PredictiveIO,
  title={Predictive Integration of Gene Ontology-Driven Similarity and Functional Interactions},
  author={Francisco Azuaje and Haiying Wang and Huiru Zheng and Olivier Bodenreider and Alban Chesneau},
  journal={Sixth IEEE International Conference on Data Mining - Workshops (ICDMW'06)},
  year={2006},
  pages={114-119}
}
There is a need to develop methods to automatically incorporate prior knowledge to support the prediction and validation of novel functional associations. One such important source is represented by the (GO)trade and the many model organism databases of gene products annotated to the GO. We investigated quantitative relationships between the GO-driven similarity of genes and their functional interactions by analyzing different types of associations in Saccharomyces cerevisiae and Caenorhabditis… CONTINUE READING
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