Predictive Computational Modeling of the Mucosal Immune Responses during Helicobacter pylori Infection

@inproceedings{Carbo2013PredictiveCM,
  title={Predictive Computational Modeling of the Mucosal Immune Responses during Helicobacter pylori Infection},
  author={Adria Carbo and Josep Bassaganya-Riera and Mireia Pedragosa and Monica Viladomiu and Madhav Marathe and Stephen Eubank and Katherine V. Wendelsdorf and Keith R. Bisset and Stefan Hoops and Xinwei Deng and Maksudul Alam and Barbara Kronsteiner and Yongguo Mei and Raquel Hontecillas},
  booktitle={PloS one},
  year={2013}
}
T helper (Th) cells play a major role in the immune response and pathology at the gastric mucosa during Helicobacter pylori infection. There is a limited mechanistic understanding regarding the contributions of CD4+ T cell subsets to gastritis development during H. pylori colonization. We used two computational approaches: ordinary differential equation (ODE)-based and agent-based modeling (ABM) to study the mechanisms underlying cellular immune responses to H. pylori and how CD4+ T cell… CONTINUE READING