Predictive, pre-natal and diagnostic genetic testing for Huntington's disease: the experience in Canada from 1987 to 2000.

@article{Creighton2003PredictivePA,
  title={Predictive, pre-natal and diagnostic genetic testing for Huntington's disease: the experience in Canada from 1987 to 2000.},
  author={Susan P Creighton and Elisabeth W. Almqvist and Daune Macgregor and B F Mestre Fern{\'a}ndez and Hermann P Hogg and J. -M. Beis and J Philip Welch and Christine Riddell and R Lokkesmoe and Mohamed Khalifa and J Mackenzie and Anaar Sajoo and Stephen Farrell and Fabienne Robert and Andrea Shugar and Anne Summers and Wendy S. Meschino and Diane Allingham-Hawkins and T L Chiu and Anita J Hunter and Judith Md Allanson and Harry Hare and Jan H. Schween and Linda Collins and Stephan Sanders and Cheryl Greenberg and S Cardwell and Edmond G. Lemire and Patrick Macleod and Michael R. Hayden},
  journal={Clinical genetics},
  year={2003},
  volume={63 6},
  pages={462-75}
}
Predictive and pre-natal testing for Huntington's Disease (HD) has been available since 1987. Initially this was offered by linkage analysis, which was surpassed by the advent of the direct mutation test for HD in 1993. Direct mutation analysis provided an accurate test that not only enhanced predictive and pre-natal testing, but also permitted the diagnostic testing of symptomatic individuals. The objective of this study was to investigate the uptake, utilization, and outcome of predictive… CONTINUE READING